STUDY OF LEUXOCYTE PEROXIDASES IN THE PERIPHERAL BLOOD AND BONE MAiuiow OF PATIENTS WITH ACUTE AND CmsoNlc GRANULOCYTIC

S 553 kowska and W. Biegaiiski. From the Hospital, L#{243}d , Poland. Pediat. Pol. 42:587589, 1967. A case of purpura fulminans with thrombocytopenia and fibrinogenopenia in the course of Sch#{246}nlein-Henoch disease was described. Treatment with epsilon amino caproic acid, Traszylol and fibrinogen had only a moderate effect on bleeding, whereas heparin treatment was followed by complete remission.-M. K. SUBARACHNOID HEMORRHAGES IN WOMEN AND MENSTRUAL BLEEDING. B. WojewskaW#{243}jcik. From the School of Medicine, Gdauisk, Poland. Pol. Tyg. Lek. 22:1154, 1967. A teniporal relationship between the onset of subarachnoid hemorrhages and menstrual bleeding was observed. The probable significance of hormonal influences on blood clotting as a cause of this phenomenon and the therapeutic implications of this assumption were discussed.-M. K. STUDIES ON THE INFLUENCE OF MAO INHIBITORS ON PLATELET ADHESIVENESS. T. Nandecki. From the Silesian School of Medicine, Katowice, Poland. Acta Med. Pol. 7:219-237, 1967. The influence of three monoaminoxidase ( MAO) inhibitors, Tersarid, Niamid and Parante, on the adhesiveness of platelets to glass was studied in patients with obliterative atherosclerosis of the lower extremities. These MAO inhibitors decreased platelet adhesiveness, while histamine, adrenalin, magnesium sulfate and prednisone given in single injections had no effect on the adhesiveness index. In vitro, adrenalin alone or with Niamid did not induce any changes. Premedication with Niamid diminished the decrease in platelet count induced regularly in patients by iv. adrenalin injection. MAO inhibitors appeared to diminish platelet adhesiveness by two mechanisms: (1) acting on platelets themselves, and (2) protecting the vascular endothelium. Their action may be mediated by inhibition of MAO activity.-M. K. SECONDARY LlPomosls OF THE SPLEEN IN THROMBOCYTOPENIA TREATED WITH STEROIDS. L. Svitok. From the University, Komensky, Bratislava, Czechoslovakia. Bratisl.L#{233}k. Listy 47:374-382, 1967. In seven cases of idiopathic thrombocytopenia treated with steroids, storage of lipids in histiocytes of the spleen was observed. The lipids, characterized as phopholipids, probably originated from disintegrating thrombocytes. The possibility of enzymatic transformation of the lipids following their phagocytosis by histiocytes was considered. -L. D. STUDIES ON THE FIBRINOLYTIC SYSTEM IN SHOCK AND THE DEFIBRINATION SYNDROME. W. Tymiuiski, E. Czestochowska, A. Lewiuzski and Z. Wojda. From the School of Medicine, Gdauisk, Poland. Pol. Tyg. Lek. 22:817-819, 1967. A method was devised for the study in vitro of the inhibitory activity of fibrinogen degradation products on the fibrinogen-fibrin conversion initiated by thrombin. The appearance of this activity in plasma seemed to be a very useful indicator of clotting disturbances in shock.-M. K. KININ-FoR 1mG SYSTEMS ACTIVATED BY PLASMIN OR BY CONTACT FACTOR. K. Buluk, M. Malofiejew and M. Czokalo. From the School of Medicine, Bialystok, Poland. Pol. Tyg. Lek. 22:1140-1141, 1967. Using two different preparations of kininogens, the authors were able to distinguish qualitatively two different kinin-forming systems in plasma. One was activated by plasmm, the other by the contact factor.-M K. THE EFFECT OF HEPARIN ON THE OxIDATIVE PHOSPHORYLATION OF THE MYOCARDIUM. V. Haviar, M. Fedor#{235}dk and 0. Lukndrovd. From the University, Komensk r, Czechoslovakia. Bratisl. L#{233}k. Listy 48: 145-149. 1967. Following administration of a single dose of heparin (150 U. per kg.) to rabbits, an increase in oxidative phosphorylation was found within 90 minutes. The mean values of the P/O ratios were increased by an average of 30 percent. A state of mild hypocoagulability was established. Hepann exerted a positive effect on oxidative phosphorylation. It did not inhibit the mitochondrial enzyme system; the increased oxygen consumption corresponded to increased ATP formation necessary for contractability of the myocardium.-L. D. For personal use only. on August 30, 2017. by guest www.bloodjournal.org From